Welcome to this weekly roundup of tales from Insider’s Enterprise co-Editor in Chief Matt Turner. Subscribe right here to get this article in your inbox each Sunday.
What we’re going over as we speak:
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How Fred DeLuca despatched Subway right into a tailspin
By the point he died in 2015, Fred DeLuca had created a secretive, complicated multibillion-dollar enterprise, and ensured nobody knew Subway the best way he did. We spoke with 20 of DeLuca’s workers, enterprise companions, and mates to know why a person obsessed along with his firm failed to guard it:
Regardless of an estimated internet value of $3 billion, DeLuca eschewed designer fits, flew coach, and berated his daughter-in-law if she dared to pay up for natural produce at Complete Meals.
Frugality did not at all times translate into modesty, although. As DeLuca grew Subway from a tiny submarine chain right into a behemoth with 27,000 places and $17 billion in world gross sales in its heyday, he refused to relinquish a lot management.
He ran Subway like a titan, sustaining a good grip on the corporate operations and surrounding himself with workers who liked and feared him. DeLuca devised a system that gave him the ultimate say and even philandered with some franchisees’ wives, two sources mentioned.
And he acquired away with it.
Learn our full profile on the person who constructed — and finally hobbled — the Subway empire:
The 46 most promising startups of 2021
We requested high enterprise capitalists to call essentially the most promising US startups thus far in 2021. The result’s an thrilling record of rising startups at each stage from a spread of industries:
Anis Uzzaman of Pegasus Tech Ventures and Hans Tung of GGV Capital each highlighted a sleep and meditation app Calm.
The pandemic shone a highlight on wellness and psychological well being. Calm was already one of many largest names in wellness tech, and it is poised to develop because the world emerges from pandemic lockdowns, Uzzaman mentioned. Earlier than the beginning of the yr, it scored a $2 billion valuation in its Collection C spherical.
“Psychological well being is usually missed but is among the many most essential facets of healthcare,” Tung mentioned.
Get the total record right here:
Why the healthcare business is skeptical concerning the new Alzheimer’s drug
Biogen’s new Alzheimer’s drug stumbled by way of testing, however will nonetheless turn into out there within the US with a price ticket of $56,000. Consultants say the drug’s approval may make it harder to enroll individuals in exams of higher remedies, and are fearful about its effectiveness:
The arrival of the primary new Alzheimer’s drug in 20 years ought to have been a second of celebration. However thus far, the healthcare business is feeling involved.
On Monday, the US Meals and Drug Administration authorized a brand new treatment referred to as Aduhelm. The drug, made by the biotech firm Biogen, is designed to take away a sticky plaque that builds up within the brains of some individuals with Alzheimer’s, which it did in scientific trials. But it surely is not clear that utilizing the drug to clear this plaque results in an enchancment in reminiscence and cognition.
“I do not consider that the drug gives advantages,” Dr. David Knopman, a neurologist on the Mayo Clinic, advised Insider.
See why the brand new medication has the well being group fearful:
How officers helped promote public faculty entry to Chinese language elite
Pegasus California Faculty appeared spectacular. The category sizes had been considerably smaller than different Val Verde faculties, and it supplied devoted night research classes overseen by college. The college assured dad and mom, in writing, that each graduate would acquire admission to one of many high 100 US universities. However there was a hitch:
Although it was part of an American public-school district, tuition and costs at Pegasus added as much as greater than $34,000 a yr. And regardless that it was largely staffed by Val Verde lecturers and directors, it was truly a boarding faculty. And regardless that it conferred a Val Verde diploma to graduates, Pegasus California Faculty was actually a personal academy solely serving Chinese language college students in Qingdao, China.
The way it acquired there, and the way it leveraged the assets and personnel of a middling public-school district for the good thing about personal buyers and rich households midway throughout the globe, is the story of 1 businessman’s quest to monetize American public schooling with the assistance of California’s strongest schooling official.
Learn our full unique report on Pegasus California Faculty right here:
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Lastly, listed below are some headlines you may need missed final week.